abstract：:The induction of the heat shock protein, HSP72, was studied in the cochlea of guinea pigs and rats subjected to a hyperthermic stress. Analyses were done by immunoblotting and immunocytochemistry at 6 and 12 h after heat shock, using a commercially available monoclonal antibody (Amersham), and by in situ hybridization...

journal_title：Hearing research

authors： Dechesne CJ,Kim HN,Nowak TS Jr,Wenthold RJ

更新日期：1992-05-01 00:00:00

abstract：:New hair cells are added to the amphibian sacculus throughout life, primarily at its outer edge. The stereociliary bundles near that edge are heterogeneous, but eventually develop the more homogeneous morphology of the overwhelming majority of mature cells near the center of the epithelium. During their development th...

journal_title：Hearing research

authors： Kelley MW,Ochiai CK,Corwin JT

更新日期：1992-04-01 00:00:00

abstract：:Furosemide is a loop diuretic which is ototoxic. Investigations have shown the stria vascularis to be the target tissue of this ototoxic drug. The purpose of the present study was to investigate the effects of furosemide on the stria vascularis in chinchillas, in controls and in animals pretreated with the above organ...

journal_title：Hearing research

authors： Rybak LP,Whitworth C,Weberg A,Scott V

更新日期：1992-04-01 00:00:00

abstract：:In the developing inner ear, a naturally occurring programmed cell death of cochleovestibular ganglion (CVG) neurons as well as peripheral and central target-derived trophic effects on survival of embryonic CVG neurons are known. To further analyze these target derived trophic interactions, spiral ganglion explants ob...

journal_title：Hearing research

authors： Lefebvre PP,Weber T,Rigo JM,Staecker H,Moonen G,Van De Water TR

更新日期：1992-03-01 00:00:00

abstract：:One of the factors which can affect the amount of temporary threshold shift (TTS) due to acoustic overstimulation is known to be the general metabolic state of the exposed subject. The present study was conducted to elucidate how preexisting intense emotional stress in awake guinea pigs could influence the TTS induced...

journal_title：Hearing research

authors： Muchnik C,Sahartov E,Peleg E,Hildesheimer M

更新日期：1992-02-01 00:00:00

abstract：:This paper reports hourly and daily monitoring of the frequencies of spontaneous otoacoustic emissions. Regular circadian variations in frequency were found in two of three subjects. Consistent monthly variations, in step with the menstrual cycle, were seen in three of four women. The circadian cycle typically showed ...

journal_title：Hearing research

authors： Bell A

更新日期：1992-02-01 00:00:00

abstract：:Recent studies have shown that the vestibular and auditory systems of some species of birds have the capacity to generate sensory hair cells postnatally. We used a traditional technique, 3H-thymidine autoradiography, and a newer method, bromodeoxyuridine immunocytochemistry, to determine whether ongoing proliferation ...

journal_title：Hearing research

authors： Roberson DF,Weisleder P,Bohrer PS,Rubel EW

更新日期：1992-01-01 00:00:00

abstract：:The uptake of two tritiated carbohydrates, D-[3H]-glucosamine and L-[3H]-fucose, to the developing rat cochlea was examined using light and electron microscopic radioautography. Both carbohydrates, administered to in vitro developing rat cochleas, shared a similar ultrastructural labeling pattern on the microvilli and...

journal_title：Hearing research

authors： Gil-Loyzaga P,Gabrion J,Remezal M,Nguyen-Than-Dao B,Uziel A

更新日期：1991-12-01 00:00:00

abstract：:Periodicity coding was studied in primary auditory cortex of the ketamine anesthetized cat by simultaneously recording with two electrodes from up to 6 neural units in response to one second long click trains presented once per 3 s. Trains with click rates of 1, 2, 4, 8, 16 and 32/s were used and the responses of the ...

journal_title：Hearing research

authors： Eggermont JJ

更新日期：1991-11-01 00:00:00

abstract：:Sound frequency and binaural response properties were determined for single neurons in the rat's inferior colliculus. Nerve cell responses in the central nucleus of the inferior colliculus were narrowly tuned and had clearly defined characteristic frequencies (CF). The central nucleus was tonotopically organized with ...

journal_title：Hearing research

authors： Kelly JB,Glenn SL,Beaver CJ

更新日期：1991-11-01 00:00:00

abstract：:We obtained just-noticeable differences (jnds) for the intensity of pure tones following a forward masker. The masker was a 100-ms burst of narrow-band noise centered at 1000 Hz presented at 90 dB SPL; the pure-tone signal was at 1000 Hz and was 25 ms in duration. The masker-signal delay was 100 ms. Under these condit...

journal_title：Hearing research

authors： Zeng FG,Turner CW,Relkin EM

更新日期：1991-10-01 00:00:00

abstract：:A derived response method of acquiring frequency specific auditory evoked potentials that utilizes a pure tone in combination with a toneburst is applied to the measurement of hearing sensitivity in guinea pigs, chinchillas and pocket gophers. Two experiments which demonstrate that thresholds acquired via tone-derived...

journal_title：Hearing research

authors： Hood LJ,Berlin CI,Heffner RS,Morehouse CR,Smith EG,Barlow EK

更新日期：1991-09-01 00:00:00

abstract：:The course, distribution and termination of single efferent fibers to the cochlea has been described in only a few animals and relatively few fibers have been studied with knowledge of their ipsilateral or contralateral origin. In order to examine the efferent fibers in the mouse, the anterograde tracer Phaseolus vulg...

journal_title：Hearing research

authors： Wilson JL,Henson MM,Henson OW Jr

更新日期：1991-09-01 00:00:00

abstract：:The recovery pattern of threshold shift (TS) and 'dynamic' changes in the stereocilia after exposure to high-level impulse noise in guinea pigs were investigated. 33 albino guinea pigs were exposed to 10 impulse noises at the rate of 1/min. The noise had peak level of 166 dB SPL and a duration of 0.1 ms. Thirteen of t...

journal_title：Hearing research

authors： Gao WY,Ding DL,Zheng XY,Ruan FM

更新日期：1991-08-01 00:00:00

abstract：:Cochleotopic representation in cortex (AI) is extensively reorganized in cats having neonatal, bilateral high frequency cochlear hearing loss. Anterior areas of AI, normally devoted to high frequencies, contain neurons which are almost all tuned to one lower frequency. This frequency corresponds, at the level of the c...

journal_title：Hearing research

authors： Harrison RV,Nagasawa A,Smith DW,Stanton S,Mount RJ

更新日期：1991-07-01 00:00:00

abstract：:This study is the continuation of the functional probing of the auditory periphery in the normal and jaundiced rat. Threshold tuning curves from normal rat auditory nerve fibers were comparable to those reported in other mammals. Life-long unconjugated hyperbilirubinemia does not appear to have a widespread, demonstra...

journal_title：Hearing research

authors： el Barbary A

更新日期：1991-07-01 00:00:00

abstract：:Systematic, slow variations of the amplitude and frequency of spontaneous otoacoustic emissions in human ears, occurring over the first 20-30 min of recording, are described. Experimental observations suggest that these variations may arise from a centrally mediated, bilateral influence on the mechanics of the ear. ...

journal_title：Hearing research

authors： Whitehead ML

更新日期：1991-06-01 00:00:00

abstract：:Acetylcholine (ACh) appears to be the major neurotransmitter liberated from olivocochlear efferents terminating on outer hair cells (OHC). Recently, cholinergic receptor epitopes were visualized at the basal pole of the OHCs. To evaluate the ACh receptor type at OHC we performed binding studies with [125I]-labelled al...

journal_title：Hearing research

authors： Plinkert PK,Zenner HP,Heilbronn E

更新日期：1991-05-01 00:00:00

abstract：:Thresholds of neurons to sounds were compared as a function of central auditory structure [ventral cochlear nucleus (VCN), dorsal cochlear nucleus (DCN), and inferior colliculus (IC)] in young and middle-aged C57BL/6J mice (multiple- and single-unit recordings) and in young and old CBA/J mice (single-unit recordings)....

journal_title：Hearing research

authors： Willott JF,Parham K,Hunter KP

更新日期：1991-05-01 00:00:00

abstract：:A technique was devised in order to study the fast electromechanical length changes of outer hair cells at low stimulus levels. Solitary outer hair cells were drawn into a glass microchamber. Length changes were evoked by the application of transcellular potentials and were detected with a photodiode. The method is no...

journal_title：Hearing research

authors： Evans BN,Hallworth R,Dallos P

更新日期：1991-04-01 00:00:00

abstract：:The origins of extrinsic projections to the guinea pig dorsal and ventral cochlear nuclei were identified by examining the retrograde transport of horseradish peroxidase conjugated to wheatgerm agglutinin following its injection into each of these divisions. Major projections originated in periolivary regions of the s...

journal_title：Hearing research

authors： Shore SE,Helfert RH,Bledsoe SC Jr,Altschuler RA,Godfrey DA

更新日期：1991-03-01 00:00:00

abstract：:Temporal modulation transfer functions (TMTF) were obtained from four European starlings (Sturnus vulgaris) using a psychophysical Go/NoGo procedure combined with the method of constant stimuli. The TMTF for a continuous, broad-band noise of 55 dB SPL had a low-pass characteristic with a cut-off frequency of 123 Hz. F...

journal_title：Hearing research

authors： Klump GM,Okanoya K

更新日期：1991-03-01 00:00:00

abstract：:Inner and outer hair cells were mechanically isolated from the guinea pig cochlea and subjected to stimuli known to induce shape changes in outer hair cells. Depolarization by 70 mM KCl which causes osmotic swelling of outer hair cells also swelled inner hair cells by approximately 8% of their volume. The application ...

journal_title：Hearing research

authors： Dulon D,Zajic G,Schacht J

更新日期：1991-03-01 00:00:00

abstract：:In order to determine the place-frequency map of the rat cochlea, iontophoretic HRP-injections were made into the cochlear nucleus at electrophysiologically characterized positions. Distribution of retrograde HRP transport in cochlear spiral ganglion cells was analysed by means of a three dimensional reconstruction of...

journal_title：Hearing research

authors： Müller M

更新日期：1991-02-01 00:00:00

abstract：:The electrically evoked auditory brainstem potential (EABR) was recorded in users of both the Nucleus cochlear implant and the Ineraid cochlear implant. The refractory properties of the EABR were evaluated by measuring the response amplitude to a two-pulse stimulus where the interpulse interval was varied. The thresho...

journal_title：Hearing research

authors： Abbas PJ,Brown CJ

更新日期：1991-01-01 00:00:00

abstract：:Three budgerigars and three zebra finches were tested for their ability to detect sinusoidal stimuli in the presence of broadband noise. Masked thresholds for 1, 2, and 4 KHz pure tones were measured with a fixed frequency condition, in which only one test frequency was presented in a session, and with an uncertain fr...

journal_title：Hearing research

authors： Okanoya K,Dooling RJ

更新日期：1990-12-01 00:00:00

abstract：:In the pigeon no influence of high doses (135 mg/kg) of furosemide on endocochlear potential and sound evoked activity in single auditory nerve fibres was found. This finding contrasts strongly to results in mammals. ...

journal_title：Hearing research

authors： Schermuly L,Vossieck T,Klinke R

更新日期：1990-12-01 00:00:00

abstract：:Using a quantitative microchemical mapping approach combined with surgical cuts of fiber tracts, the contributions of centrifugal pathways to choline acetyltransferase activity were mapped three-dimensionally in the cat cochlear nucleus. Large reductions of choline acetyltransferase activity, averaging 70%, were measu...

journal_title：Hearing research

authors： Godfrey DA,Beranek KL,Carlson L,Parli JA,Dunn JD,Ross CD

更新日期：1990-11-01 00:00:00

abstract：:During noise-induced temporary threshold shift cytoplasmic vacuoles increase in the synaptic region of auditory hair cells. This structural change in the presynaptic region suggests that afferent synapses between hair cells and auditory nerve fibers fail during the period of threshold elevation, and that synaptic fati...

journal_title：Hearing research

authors： Mulroy MJ,Fromm RF,Curtis S

更新日期：1990-11-01 00:00:00

abstract：:The olivocochlear bundle was sectioned at the floor of the fourth ventricle in a series of cats. From three to thirty weeks post-operatively, recordings were made from single auditory-nerve fibers. Tuning curves, spontaneous discharge rates, and rate-level functions for tones at the characteristic frequency were measu...

journal_title：Hearing research

authors： Liberman MC

更新日期：1990-11-01 00:00:00

abstract：:The latency, the rise time and the influence of the acoustic reflex on sound transmission were investigated in the adult rat during ketamin anesthesia. This was done by recordings of the cochlear microphonics (CM) and electromyographic (EMG) recordings of the reflex responses of the tensor tympani muscle. The acoustic...

journal_title：Hearing research

authors： van den Berge H,Kingma H,Kluge C,Marres EH

更新日期：1990-10-01 00:00:00

abstract：:We have analyzed a model for the motion of hair bundles of hair cells at high frequencies. In the model, hair-cell organs are represented as a system of rigid mechanical structures surrounded by fluid. A rigid body, that represents a hair bundle, is hinged to a vibrating plate that represents the sensory epithelium. T...

journal_title：Hearing research

authors： Freeman DM,Weiss TF

更新日期：1990-09-01 00:00:00

abstract：:Certain hair cells of fish exhibit strong immunoreactivity to an S-100 antibody. By their spatial locations in the utricle and saccule, these hair cells appear to possess a relatively short kinocilium and a roughly ovoid cell shape. In the utricle, these cells are predominantly located in the striola. In the saccule, ...

journal_title：Hearing research

authors： Saidel WM,Presson JC,Chang JS

更新日期：1990-08-01 00:00:00

abstract：:In Menière's disease, the increase of extracellular potassium concentration in the perilymph is thought to play a key role in determining the progressive loss of cochlear hair cells. In this paper, we describe a serum-free culture preparation of hair cells from 5 day-old rat and report the release by the cochlea, in r...

journal_title：Hearing research

authors： Lefebvre PP,Weber T,Rigo JM,Delree P,Leprince P,Moonen G

更新日期：1990-08-01 00:00:00

abstract：:In order to investigate the localization and the type(s) of excitatory amino acid receptors in the frog vestibular system, the exogenous amino acid agonists Quisqualic acid, Kainic acid and N-methyl-D-aspartic acid were tested on the sensory organ of semicircular canals. Intracellular recordings of the resting dischar...

journal_title：Hearing research

authors： Prigioni I,Russo G,Valli P,Masetto S

更新日期：1990-07-01 00:00:00

abstract：:The ototoxic effects of salicylates, reversible hearing loss and tinnitus, are well documented. However, the pharmacological mechanisms underlying these changes in cochlear function are not well understood. The studies reported here were an investigation of the site and mechanism of salicylate ototoxicity through an e...

journal_title：Hearing research

authors： Stypulkowski PH

更新日期：1990-06-01 00:00:00

abstract：:Previous studies have shown a reduction of the ototoxicity of furosemide in chinchillas pretreated with organic acid transport inhibitors. The current studies were designed to investigate whether such a protective effect could be observed in chinchillas receiving ethacrynic acid. Chinchillas weighing 400-600 g were in...

journal_title：Hearing research

authors： Rybak LP,Whitworth C,Scott V

更新日期：1990-06-01 00:00:00

abstract：:This report describes the effects of L-glutamate (Glu) introduced into the perilymph of scala tympani on the spontaneous and tone-evoked activity of guinea pig single primary auditory afferents. Concentrations below 2 mmol/l were in general ineffective, while a concentration of 5 mmol/l caused a marked decrease of the...

journal_title：Hearing research

authors： Gleich O,Johnstone BM,Robertson D

更新日期：1990-05-01 00:00:00

abstract：:The known structural and functional features of the inferior colliculus provided an advantageous substrate for examining the outcome of neural transplantation. In the present study, tissue from the midbrain tectum of Sprague-Dawley rat fetuses was removed at 15, 16 and 19 days of gestation (E15, E16 and E19), incubate...

journal_title：Hearing research

authors： Zrull MC,Coleman JR

更新日期：1990-05-01 00:00:00

abstract：:Left-handed individuals show a 4 ms later Wave Pb in the 45-60 ms latency range of the auditory middle latency response (MLR) than right-handed individuals. Examination of auditory evoked potentials in fifteen right-handed and fifteen left-handed normal hearing adults showed that this difference was not evident in tim...

journal_title：Hearing research

authors： Hood LJ,Martin DA,Berlin CI

更新日期：1990-04-01 00:00:00